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Effect of ATXII on opening modes of myocyte sodium channel, action potential and QT intervals of ECG

Li Cizhen, Wang Hongwei, Liu Jianli, Liu Kai, Yang Zhifang, Liu Yuanmou

Department of Physiology,Shanghai Second Medical University.Shanghai 200025

Abstract

The results suggest that the dynamics or modes of Na channel play an important role in determining the action potential duration and the QT interval of ECG. The dynamical changes in Na channels induced by genetic mutation may be partially responsible for the long QT syndrome.

Key words: Sodium channel;ATXII;Action potential;ECG;long QT syndrome

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Citing This Article：

Li Cizhen, Wang Hongwei, Liu Jianli, Liu Kai, Yang Zhifang, Liu Yuanmou. Effect of ATXII on opening modes of myocyte sodium channel, action potential and QT intervals of ECG. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).