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Changes in the state of phosphorylation of DARPP-32 of gerbil striatum during ischemia

Sun Yafeng, Tang Fangming, Wang Ran, Zhang Guangyi, Jin Guozhang

Research Center of Biochemistry and Molecular Biology,Xuzhou Medical College.Xuzhou 221002,Jiangsu；China

Abstract

Transient forebrain ischemia had no effect on the immunoreaction of DARPP-32 in striatum, but the state of phosphorylation of DARPP-32 showed a significant change. The [~(32)P] phosphate incorporation in DARPP-32 decreased after 2, 7 or 10 min of ischemia, but increased after a 5-min ischemia. In contrast, the result of back-phosphorylation in vivo was opposite to that obtained in vitro.

Key words: Cerebral ischemia;Mongolian gerbil;DARPP-32;Back phosphoiylation;Striatum

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Citing This Article：

Sun Yafeng, Tang Fangming, Wang Ran, Zhang Guangyi, Jin Guozhang. Changes in the state of phosphorylation of DARPP-32 of gerbil striatum during ischemia. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).