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Substance P depresses GABA-activated currents in cultured hippocampal pyramidal neurons of rats

Xiong Shunhua, Li Zhiwang, Fan Youzhen, Wang Mingjiang, Wei Jingbo

Department of Physiology,Yunyang Medical College.Shiyan 442000,Hubei；China；Department of Physiology,Hubei Medical University.Wuhan 430071,Hubei

Abstract

Intracelllar application of H7, a potent inhibitor of PKC, abolished inhibition of I_(GABA) by SP, suggesting that the inhibition of I_(GABA) by SP may be a result of intracellular phosphorylation of the GABA_(A) receptor.

Key words: GABAA receptor;Substance P;Whole-cell-patch-clamp recording;Hyppcampl pyramidal neurons;Inhibition

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Citing This Article：

Xiong Shunhua, Li Zhiwang, Fan Youzhen, Wang Mingjiang, Wei Jingbo. Substance P depresses GABA-activated currents in cultured hippocampal pyramidal neurons of rats. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).