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Role of mitogen-activated protein kinase in the inhibition of myocardial hypertrophy by nitric oxide in renovascular hypertensive rats

Lu Wei, Liu Peiqing, Wang Tinghuai, Gong Suzhen, Fu Shigan, Pan Jingyun

Department of Physiology,Sun Yat-Sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The aim of this study was to examine the effects of L-arginine, a nitric oxide (NO) precursor, on protein expression of endothelial nitric oxide (eNOS), nitrite/nitrate content, protein expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) and the activity of mitogen-activated protein kinase (MAPK) in cardiac tissues in renovascular hypertensive rats (RHR).

Key words: Myocardial hypertrophy; endothelial nitric oxide (eNOS);;;;

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Citing This Article：

Lu Wei, Liu Peiqing, Wang Tinghuai, Gong Suzhen, Fu Shigan, Pan Jingyun. Role of mitogen-activated protein kinase in the inhibition of myocardial hypertrophy by nitric oxide in renovascular hypertensive rats. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).