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Effect of aldosterone on the secretion of endothelin by ventricular fibroblasts

Gong Suzhen, Liu Peiqing, Lu Wei, Wang Tinghuai, Fu Shigan, Tan Zhi, Pan Jingyun

Department of Physiology,Sun Yat-Sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The results showed that aldosterone (1×10~(-7) mol/L) promoted the expression of ppET-1 mRNA, which began to increase in 2 hours and attained the highest level in 4 hours, thereafter decreased; aldosterone increased the endothelin level in ventricular fibroblasts and fibroblast conditioned growth medium (FCGM) as well, which was blocked by spironolactone (1×10~(-6) mol/L), an aldosterone receptor antagonist. The results suggest that aldosterone can increase endothelin secretion by ventricular fibroblasts, which can be inhibited by its receptor antagonist spironolactone.

Key words: aldosterone;spironolactone;radioimmunoassay for endothelin;ppET-1 mRNA;ventricular

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Citing This Article：

Gong Suzhen, Liu Peiqing, Lu Wei, Wang Tinghuai, Fu Shigan, Tan Zhi, Pan Jingyun. Effect of aldosterone on the secretion of endothelin by ventricular fibroblasts. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).