Issue Archive

MK-801 attenuates NOS expression and NO content in the spinal cord of rats with inflammatory pain

Zeng Jingbo, Li Wenbin, Li Qingjun, Chen Xiaoling, Zhou Aimin, Ling Yiling

Department of Pathophysiology,Basic Medical Institute,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results showed that the NOS expression and NO contents significantly increased 24 h after formalin injection, which were substantially inhibited when MK-801 was intrathecally injected 15 min prior to formalin injection or 12 h after formalin injection.

Key words: inflammatory pain and hyperalgesia;Nitric oxide;nitric oxide synthase;NMDA receptor;MK-801;Spinal cord

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Zeng Jingbo, Li Wenbin, Li Qingjun, Chen Xiaoling, Zhou Aimin, Ling Yiling. MK-801 attenuates NOS expression and NO content in the spinal cord of rats with inflammatory pain. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).