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Inhibitory effect of genistein on the proliferation of the anterior pituitary cells of rats

Zhang Qinghong, Hu Yuzhen, Zhou Shizhen, Wang Fuzhou

Department of Physiology,Fourth Military Medical University.Xi^an 710032,Shaanxi

Abstract

Genistein significantly inhibited the proliferation of rat anterior pituitary cells and mouse AtT-20 cells. Genistein (50 and 100 #mu#mol/L) blocked the proliferation of AtT-20 cells at G_(0)/G_(1) and G_(2)/M phases and evoked an apoptotic peak of these cells with an apoptotic ratio of 19.9% and 36.4%. The apoptotic cells were also observed under the electron microscope. In consequence, genistein, as a tyrosine kinase inhibitor, can significantly inhibit the proliferation of pituitary cells possibly by inducing apoptosis, and the tyrosine kinase activity may play a key role in the proliferation and differentiation of pituitary cells.

Key words: genistein;Pituitary;Proliferation;Apoptosis;tyrosine kinase inhibitor

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Citing This Article：

Zhang Qinghong, Hu Yuzhen, Zhou Shizhen, Wang Fuzhou. Inhibitory effect of genistein on the proliferation of the anterior pituitary cells of rats. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).