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ICAM-1 expression of rat brain microvascular endothelial cells caused by fluid shear force

Song Xiaoyan, Zeng Yanjun, Li Caixia, Liao Donghua, Hu Jinlin, Hao Yanlei

Biomechanics and Medical Information Institute,Beijing Polytechnic University.Beijing 100022；China；Laboratory of Neuroscience,Chinese PLA General Hospital.Beijing 100853

Abstract

We studied the effect of shear stress (SS) on intercellular adhesion molecule-1 (ICAM-1) expression of rat brain microvascular endothelial cells (RBMECs) using the parallel plate flow chamber method. It was demonstrated that RBMECs showed a time-dependent, but not a force-dependent, upregulation in ICAM-1 expression. Endothelial cell surface expression of ICAM-1 in the supernatants of RBMECs exposed to SS was not changed, thus excluding the possibility that the upregulated expression is due to the factors synthesized by these cells.

Key words: shear force;RBMECs;ICAM-1

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Citing This Article：

Song Xiaoyan, Zeng Yanjun, Li Caixia, Liao Donghua, Hu Jinlin, Hao Yanlei. ICAM-1 expression of rat brain microvascular endothelial cells caused by fluid shear force. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).