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Electrophysiological effects of calcitonin gene-related peptide on isolated sinoatrial node of the rabbit

Guo Lianfeng, Niu Weizhen, Jiao Xiaohui, Liu Beiying

Departments of Cardiovascular Physiology,Capital University of Medical Science.Beijing 100054

Abstract

It was found : (1) CGRP(1 nmol/L) had no effect on AP configuration ; CGRP (10 nmol/L) increased the maximal diastolic potential,AP amplitude and depolarization velocity of 0 and 4 phases, and decreased sinus cycle length and AP duration. After applying CGRP for 20 min the above effects reached to a maximum . CGRP(100 nmol/L) caused arrhythmia in the SAN . Calcium channel antagonists, CdCl_(2) and verapamil attenuated the electrophysiological changes in AP of SAN induced by CGRP (20 nmol/L).

Key words: CGRP;Sinoatrial node;Action potential;Cadmium chloride;Verapamil

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Citing This Article：

Guo Lianfeng, Niu Weizhen, Jiao Xiaohui, Liu Beiying. Electrophysiological effects of calcitonin gene-related peptide on isolated sinoatrial node of the rabbit. Acta Physiol Sin 2000; 52 (2): (in Chinese with English abstract).