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Fibronectin or RGD peptide promotes nitric oxide synthesis of rabbit bronchial epithelial cells

Qin Xiaoqun, Xiang Yang, Luo Ziqiang, Zhang Changqing, Sun Xiuhong

Department of Physiology,Xiang-Ya Medical School,University of South-Central China.Changsha 410078,Hunan

Abstract

To find out whether the extracellular matrix component fibronectin plays a regulatory and protective role in bronchial epithelial cells, the present study was undertaken to detect the NO released from primary cultured rabbit bronchial epithelial cells (BEC) and the activity of NO synthesase (NOS) in cells. Stress with ozone was taken as the positive control, and the effects of fibronectin (Fn) or its specific sequence Arg-Gly-Asp (RGD peptide) was observed.

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Citing This Article：

Qin Xiaoqun, Xiang Yang, Luo Ziqiang, Zhang Changqing, Sun Xiuhong. Fibronectin or RGD peptide promotes nitric oxide synthesis of rabbit bronchial epithelial cells. Acta Physiol Sin 2000; 52 (6): (in Chinese with English abstract).