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Cholecystokinin-octapeptide alleviates tumor necrosis factor-alpha induced changes in rabbit pulmonary arterial reactivity and injuries of endothelium in vitro

Meng Aihong, Ling Yiling, Wang Dianhua, Wu Zhenyong, Li Shujin, Zhu Tienian

Department of Pathophysiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

To explore the mechanism underlying cholecystokinin-octapeptide (CCK-8) induced attenuation of pulmonary arterial hypertension (PAH) in endotoxic shock, the effects of CCK-8 on the changes in rabbit pulmonary arterial reactivity induced by tumor necrosis factor-alpha (TNF-#alpha#) were observed with the isolated arterial ring technique, and the ultrastructure of pulmonary arterial endothelium was observed under a scanning electron microscope.

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Meng Aihong, Ling Yiling, Wang Dianhua, Wu Zhenyong, Li Shujin, Zhu Tienian. Cholecystokinin-octapeptide alleviates tumor necrosis factor-alpha induced changes in rabbit pulmonary arterial reactivity and injuries of endothelium in vitro. Acta Physiol Sin 2000; 52 (6): (in Chinese with English abstract).