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Cardiovascular effects of lateral intracerebroventricular injection of L-securinine

Zhao Xiaoyan, Jiang Zhengyao, Peng Jianzhong

Clinic of Cardionephretic internal medicine,Fifth Hospital of PLA.Yinchuan 750004,Ningxia；China

Abstract

To investigate cardiovascular effects of changed GABA ergic tonic activation in periventricular forebrain, arterial pressure (AP), heart rate (HR) and renal sympathetic nerve discharge (RSND) were recorded in anesthetized rats when L-securinine (L-Sec) was asministered into the laternal intracerebro-ventricle. L-Sec elicited dose-dependent increases in RSND, AP and HR, which were much weaker than those of bicuculline. L-Sec antagonized the sympatho-inhibitory and depressor effects evoked by both muscimol and baclofen.

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Citing This Article：

Zhao Xiaoyan, Jiang Zhengyao, Peng Jianzhong. Cardiovascular effects of lateral intracerebroventricular injection of L-securinine. Acta Physiol Sin 2000; 52 (6): (in Chinese with English abstract).