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Relationship between memory enhancement induced by nitric oxide donor and brain ADP-ribosyltransferase in rats

Li Congde, Zhang Shiyi, Yuan Bo

Medical School,Hubei Three Canyon University.Yichang 443003,Hubei；China

Abstract

In order to explore the signal transduction pathway of nitric oxide (NO) related to learning and memory, the effects of intracerebral ventricular injection (icv) of NO donor sodium nitroprusside (SNP) alone or along with ADP-ribosyltransferase (ADPRT) inhibitor nicotinamide (NIC) on learning and memory behavior were investigated in rats. Brain ADPRT activity was analyzed using high performance liquid chromatography. The results showed that SNP (0.36#mu#g, icv) facilitated short-term and long-term memory in passive avoidance response and elevated learning and memory ability in active avoidance response. NIC (1.5mg, icv) blocked the effect of SNP.

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Citing This Article：

Li Congde, Zhang Shiyi, Yuan Bo. Relationship between memory enhancement induced by nitric oxide donor and brain ADP-ribosyltransferase in rats. Acta Physiol Sin 2000; 52 (6): (in Chinese with English abstract).