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Inhibition of transmembrane K~(+) currents in mammalian ventricular myocytes by antiarrhythmic agent RP62719

Li Yurong, Yang Baofeng, Xu Changqing, Zhou Jin, Yang Yongbin, Zhang Jiye, Sun Mingzhi

Department of Physiology,Harbin Medical University.Harbin 150086,Heilongjiang；China；Department of Pathophysiology,Harbin Medical University.Harbin 150086,Heilongjiang

Abstract

The effect of RP62719 on the inward rectifier K~(+) current (I_(KI)), transient outward K~(+) current (I_(to)) and delayed outward K~(+) current (Ik) in isolated cardiac myocytes was determined using the whole cell patch clamp technique in guinea pig and dog.

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Citing This Article：

Li Yurong, Yang Baofeng, Xu Changqing, Zhou Jin, Yang Yongbin, Zhang Jiye, Sun Mingzhi. Inhibition of transmembrane K~(+) currents in mammalian ventricular myocytes by antiarrhythmic agent RP62719. Acta Physiol Sin 2000; 52 (5): 427-430 (in Chinese with English abstract).