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A study on the electrophysiological heterogeneity of rabbit ventricular myocytes--The effects of ischemia on action potentials and potassium currents

Qi Xiaoyan, Shi Weibin, Wang Haihong, Zhang Zhixiong, Xu Youqiu

Department of Physiology,Shanghai University of Traditional Chinese Medicine.Shanghai 200032；China

Abstract

With the whole-cell variant patch-clamp technique, action potentials (AP) and outward potassium currents of rabbit ventricular myocytes isolated from subendocardium and subepicardium were recorded and their changes were observed under normal and ischemia conditions. It is suggested that the increase of steady-state outward potassium currents during ischemia is mainly due to the opening of I_(K-ATP) channels as a result of the deficiency of intracellular ATP caused by ischemia.

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Citing This Article：

Qi Xiaoyan, Shi Weibin, Wang Haihong, Zhang Zhixiong, Xu Youqiu. A study on the electrophysiological heterogeneity of rabbit ventricular myocytes--The effects of ischemia on action potentials and potassium currents. Acta Physiol Sin 2000; 52 (5): 360-364 (in Chinese with English abstract).