Issue Archive

Effect of central administration of motilin on the activity of gastric-related neurons in brain stem and gastric motility of rats

Tang Ming, Zhang Hongyan, Jiang Zhengyao, Xu Luo, Peeters T L

Department of Physiology,College of Medicine,Qingdao University.Qingdao 266021,Shandong

Abstract

To investigate the effect of microinjection of motilin into ventral medail hypothalamus (VMH) or intracerebroventricle (icv) on gastric motility, extracellular unit responses of dorsal vagal complex (DVC) in anesthetized rats and gastric motility of conscious rats were recorded. The results are as follows. (1) The firing rate of gastric distention related neurons in DVC was modified. (2) VMH and icv administration of motilin induced obvious enhancement in gastric motility. (3) The effect of motilikn on gastric motility was abolished by vagotomy.

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Tang Ming, Zhang Hongyan, Jiang Zhengyao, Xu Luo, Peeters T L. Effect of central administration of motilin on the activity of gastric-related neurons in brain stem and gastric motility of rats. Acta Physiol Sin 2000; 52 (5): 416-420 (in Chinese with English abstract).