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Modulation of GABA-activated currents by oxytocin in rat dorsal root ganglion neurons

Tan Zhenjun, Wei Jingbo, Li Zhiwang, Shao Mei, Hu Qisheng, Peng Biwen

Department of Physiology,Hubei Medical University.Wuhan 430071,Hubei；China

Abstract

Experiments were performed on freshly isolated dorsal root ganglion (DRG) neurons of rat. GABA_(A)-activated currents were recorded using the whole-cell patch clamp technique. The majority of the neurons (48/52, 90.5%) were sensitive to GABA (10~(-6)-10~(-3) mol/L). The results suggest that the enhancement of GABA-activated currents by OT may suppress primary sensory transmission by potentiating pre-synaptic inhibition of GABA.

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Tan Zhenjun, Wei Jingbo, Li Zhiwang, Shao Mei, Hu Qisheng, Peng Biwen. Modulation of GABA-activated currents by oxytocin in rat dorsal root ganglion neurons. Acta Physiol Sin 2000; 52 (5): 381-384 (in Chinese with English abstract).