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Effects of berberine on intracellular calcium concentration in smooth muscle cells of guinea pig colon

Cao Jiwang, Luo Hesheng, Yu Baoping, Shen Zhixiang, Yu Jieping

Digestive Disease Research Division,The First Affiliated Hospital of Hubei Medical University.Wuhan 430060,Hubei

Abstract

The purpose of the present investigation is to study how berberine (Ber) affect the intracellular free calcium concentration ([Ca~(2+)]_(i)) of the smooth muscle cells of guinea pig colon by means of biwavelength spectrophotometry with Fura 2-AM in a cell suspension specimen. The results suggest that Ber exerts an inhibitory effect on the extracellular Ca~(2+) influx and the Ca~(2+) release from intracellular stores.

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Citing This Article：

Cao Jiwang, Luo Hesheng, Yu Baoping, Shen Zhixiang, Yu Jieping. Effects of berberine on intracellular calcium concentration in smooth muscle cells of guinea pig colon. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).