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Effects of ketamine on neuronal activity of the spinal dorsal horn in rats with unilateral hindpaw inflammation

Guo Hua, Li Jingjin, Lu Guowei

Department of Neurobiology,Capital University of Medical Sciences.Beijing 100054

Abstract

A total of 32 units were extracellularly recorded from the spinal dorsal horn of rats. Unitary discharges evoked by stimulation of A and C fiber in ipsilateral lateral and medial plantar nerve were increased after carrageenan injection to be planter area. The evoked responses to both A and C fiber were significantly decreased or even disappeared after administration of ketamine. The windup phenomenon was observed in neurons located deeply in the dorsal horn following carrageenan injection and was significantly suppressed or abolished after ketamine administration.

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Citing This Article：

Guo Hua, Li Jingjin, Lu Guowei. Effects of ketamine on neuronal activity of the spinal dorsal horn in rats with unilateral hindpaw inflammation. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).