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Role of calcineurin in cardiac fibroblast proliferation stimulated by angiotensin II

Xu Song, Fu Mingui, Xu Yufeng, Pang Yongzheng, Tang Chaoshu

Institute of Cardiovascular Research,the First Hospital,Beijing Medical University.Beijing 100034

Abstract

~(3)H-TdR incorporation, activity of CaN and intracellular calcium concentration were measured. ~(3)H-TdR incorporation of Ang II-stimulated fibroblasts was 72% higher than control (P<0.01), which was inhibited by CsA (0.1-10 #mu#mol/L) in a dose-dependent manner. Intracellular Ca~(2+) level and CaN activity of Ang II-stimulated fibroblasts were respectively 112% (P<0.01) and 17% (P<0.05) higher than control.

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Citing This Article：

Xu Song, Fu Mingui, Xu Yufeng, Pang Yongzheng, Tang Chaoshu. Role of calcineurin in cardiac fibroblast proliferation stimulated by angiotensin II. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).