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Regulation of inflammatory responses by MAPK signal transduction pathways

Jiang Yong, Gong Xiaowei

Department of Pathophysiology and Key Laboratory for Shock and Microcirculation of PLA,First Military Medical University.Guangzhou 510515,Guangdong

Abstract

Mitogen-activated protein kinase (MAPK), which is one of the important signal transduction systems in organisms, is involved in many cellular processes, such as cell growth, development, division, differentiation, death and coordination of cellular functions, and etc. Four subfamilies of MAP kinases, i.e. ERK, JNK/SAPK, p38/RK and ERK5/BMK1, have been identified and cloned in mammalian cells. These MAP kinases are activated by many proinflammatory stimuli and play an important role in the pathogenesis and development of inflammation. In this article recent advances in the study of the mechanisms underlying activation of MAPKs in infection and inflammation and the molecular basis of specific inhibitors for MAPKs are reviewed, in special reference with the perspective prevention and treatment of inflammation by these kinases.

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Citing This Article：

Jiang Yong, Gong Xiaowei. Regulation of inflammatory responses by MAPK signal transduction pathways. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).