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Changes in the iron uptake of bone marrow cell in exercised rats

Xiao Desheng, Qian Zhongming

Department of physiology, Zhenjiang Medical Collage. Zhenjiang 212001；China

Abstract

At the end of a 6-month period, the bone marrow cells were freshly isolated . The Tf receptor number on the surface of erythroblasts was 890 150±164 849 molecules/cell in SG and 2 175 360±462 737 molecules /cell in EG(P<0.05) . No significant difference in dissociation constant value was found between the two groups . The plateau of Tf internalization and the rates of cellular iron accumulation in EG were significantly higher than controls . Amounts of Tf-bound iron and Fe(II uptake into cytosolic or stromal fractions were significantly higher in EG than those in cytosolic or stromal fractions of SG . With respect to the specific process of Fe(II), the michaelis constant value of iron uptake into the cytosol, rather than the stroma,in EG was significantly lower than that in SG;and the maximum rate of iron uptake into the stroma in EG was significantly higher than that in SG.

Key words: Iron metabolism;Exercise;Transferrin receptor;Bone marrow

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Citing This Article：

Xiao Desheng, Qian Zhongming. Changes in the iron uptake of bone marrow cell in exercised rats. Acta Physiol Sin 2000; 52 (2): (in Chinese with English abstract).