Issue Archive

[Research progress of TRPV4 and cerebral ischemic reperfusion injury.] [Article in Chinese]

DING Hao, LIN Ye-Xin, SHEN Qi-Wen, PAN Zhi, WANG Zhen-Chao, CHEN Lei

Class 4 Grade 2012, Seven-year Program of Clinical Medicine； Department of Physiology, Nanjing Medical University, Nanjing 210029, China

Abstract

Transient receptor potential vanilloid 4 (TRPV4) channel is a member of transient receptor potential superfamily. TRPV4 is selectively permeable to calcium. Activation of the TRPV4 channel induces an increase in intracellular calcium concentration and plays an important role under physiological and pathological conditions. Especially, there is evidence showing that TRPV4 is involved in cerebral ischemic reperfusion injury. The present paper reviewed some research progress about the role of TRPV4 in cerebral ischemic reperfusion injury.

Key words: transient receptor potential vanilloid 4 channel; calcium; cerebral ischemic reperfusion

Received: 2015-06-12　　Accepted: 2015-07-29

Corresponding author: 陈蕾　　E-mail: chenl@njmu.edu.cn

Citing This Article：

DING Hao, LIN Ye-Xin, SHEN Qi-Wen, PAN Zhi, WANG Zhen-Chao, CHEN Lei. [Research progress of TRPV4 and cerebral ischemic reperfusion injury.] [Article in Chinese]. Acta Physiol Sin 2015; 67 (5): 527-532 (in Chinese with English abstract).