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[Cellular function of microRNA-15 family.] [Article in Chinese]

LIU Li-Feng, WANG Yu^*

Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China

Abstract

microRNAs (miRNAs) are non-coding endogenous short RNAs which are involved in regulating gene expression at the post-transcriptional level. miR-15 family is increasingly found to play great roles in important cell processes, such as apoptosis, cell differentiation and stress response. Growing evidence indicates that miR-15 family members are implicated in tumor, cardiovascular disease and neurodegenerative disease. miRNAs have emerged as a new promising subset of therapeutic targets. The present paper reviewed the important function of miR-15 family and new approaches for miRNA-based therapy.

Key words: microRNAs; miR-15 family; apoptosis; neoplasm; cardiovascular disease

Received: 2011-06-28　　Accepted: 2011-08-23

Corresponding author: 王禹　　E-mail: wangyuheart@163.com

Citing This Article：

LIU Li-Feng, WANG Yu. [Cellular function of microRNA-15 family.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (1): 101-106 (in Chinese with English abstract).