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Effects of dopamine receptor agonists on the cAMP content in arteries of the rabbit

Zhu Lin, Zhao Rongrui, Zhang Weifang

Department of Pharmacy,The First Affiliated Hospital,Henan Medical University.Zhengzhou 450052,Henan；China

Abstract

Effects of selective dopamine-1 (DA_(1)) receptor agonist fenoldopam and dopamine-2 (DA_(2)) receptor agonist propyl-butyl-dopamine (PBDA) on the cAMP generation system in renal, pulmonary, mesenteric and femoral arteries of rabbits were studied. Findings suggest the presence of DA_(1) receptors mediating the cAMP generation system in renal, pulmonary and mesenteric arteries, but only DA_(2) receptors in femoral artery, and both DA_(1) and DA_(2) receptors in mesenteric artery. PBDA inhibits the AC activity via stimulation of DA_(2) receptors and increases the AC activity via stimulation of DA_(1) receptors.

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Citing This Article：

Zhu Lin, Zhao Rongrui, Zhang Weifang. Effects of dopamine receptor agonists on the cAMP content in arteries of the rabbit. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).