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Nitric oxide changes aortic function in rats with renal hypertension

Guo Yimin, Zhu Xiaonan, Pan Jingyun

Department of Physiology,Wenzhou Medical College.Wenzhou 325027,Zhejiang；China

Abstract

This work was undertaken to investigate the effect of nitric oxide (NO) on aortic function of two-kidney and one-clip (2K1C) rats with renal hypertension. Animals were divided into 5 groups: the sham operation, 2K1C, captopril, L-arginine and L-NAMe groups. Results suggest that deficiency of nitric oxide production and increase in renin-angiotensin system activity may contribute to vascular endothelial dysfunction of 2K1C rats, and these factors may be involved in development and maintenance of 2K1C renal hypertension.

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Citing This Article：

Guo Yimin, Zhu Xiaonan, Pan Jingyun. Nitric oxide changes aortic function in rats with renal hypertension. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).