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Ischemic preconditioning reduces cardiomyocytic apoptosis in rabbit heart in vivo

Ding Yanfeng, Zhang Manman, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The effects of ischemia-reperfusion (IR) and ischemic preconditioning (IP) on hemodynamics, epicardial electrography, myocardial infarct size, cardiomyocytic apoptosis and gene proteins involving apoptosis (Fas, Bcl-2 and Bax) were observed in aneasthetized rabbit myocardium. It is suggested that IP decreases cardiomyocytic apoptosis induced by IR and this action is mediated by the reduction of Fas protein expression.

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Citing This Article：

Ding Yanfeng, Zhang Manman, He Ruirong. Ischemic preconditioning reduces cardiomyocytic apoptosis in rabbit heart in vivo. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).