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Comparison of inhibitory effects of three natriuretin peptides on the proliferation of pulmonary artery smooth muscle cells of rats

Dong Mingqing, Zhu Miaozhang, Yu Jun, Shang Lijun, Feng Huasong

Department of Physiology,Fourth Military Medical University.Xi^an 710032,Shaanxi；China

Abstract

The inhibitory effects of atrial natriuretic peptide (ANP), C-type natriuretic peptide (CNP) and vasonatrin peptide (VNP) on the proliferation of pulmonary artery smooth muscle cells (PASMCs) were compared in rats. Total protein and OD value of MTT were detected in cultured rat PASMCs to examine the influence of the three peptides on PASMC proliforation induced by phorbol 12-myristate 13-acetate (PMA). The results show that PMA (10~(-9)-10~(-7) mol/L) increased and VNP (10~(-8)-10~(-6) mol/L), ANP and CNP (10~(-7)-10~(-6) mol/L) decreased the total protein and OD value in a dose-dependent manner (P<0.05).

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Citing This Article：

Dong Mingqing, Zhu Miaozhang, Yu Jun, Shang Lijun, Feng Huasong. Comparison of inhibitory effects of three natriuretin peptides on the proliferation of pulmonary artery smooth muscle cells of rats. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).