Issue Archive

Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats

Cao Junli, Zeng Yinming, Zhang Licai, Duan Shiming

Department of Anesthesiology,Affiliated Hospital of Xuzhou Medical College.Xuzhou 221002,Jiangsu；China

Abstract

Fos immunocytochemistry, NADPH-d histochemistry and Fos/NADPH-d double-labeling method were used to study the changes in formalin-induced Fos, NADPH-d positive and Fos/NADPH-d double-labeled neurons in the spinal cord of morphine-tolerant rats. It is suggested that NO is involved in the increase of formalin-induced Fos-LI in the spinal cord of morphine-tolerant rats and may play an important role in the development of morphine tolerance.

Key words: Morphine;Tolerance;Fos-LI;Nitric oxide synthase

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Cao Junli, Zeng Yinming, Zhang Licai, Duan Shiming. Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).