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Cardiocyte hypertrophy induced by cultured neonatal rat ventricular fibroblast conditioned growth medium

Gong Suzhen, Liu Peiqing, Lu Wei, Fu Shigan, Pan Jingyun

Department of Physiology,Sun Yat-sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The present work demonstrated that cultured neonatal rat ventricular fibroblast conditioned growth medium (FCGM) could significantly increase cell surface area and protein content and promote [~(3)H]-Leucine incorporation on neonatal rat cardiomyocyte. The above effect was strongest on the third day, and was dose-dependent. BQ_(123), on ET-A receptor antagonist, significantly blocked the effect, while CV11974, an AngII I-type receptor antagonist, and regitin, an #alpha#-adrenergic receptor antagonist, did not.

Key words: Fibroblast;Myocyte hypertrophy;Cell;Culture;Heart

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Citing This Article：

Gong Suzhen, Liu Peiqing, Lu Wei, Fu Shigan, Pan Jingyun. Cardiocyte hypertrophy induced by cultured neonatal rat ventricular fibroblast conditioned growth medium. Acta Physiol Sin 2000; 52 (1): (in Chinese with English abstract).