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Effects of c-erbB_(2) on the hCG-induced progesterone production of rat luteal cells

Jin Xuan, Wang Lian, Zheng Yuehui, Zhong Zhisheng, Kuang Haibin

Department of Physiology,Jiangxi Medical College.Nanchang 330006,Jiangxi

Abstract

Antisense c-erbB_(2) ODN inhibited hCG-induced progesterone production in a dose-dependent manner; and the percentage of luteal cells stained for c-erbB_(2) protein was decreased. But nonsense tat ODN had no similar effect. The effect of dbcAMP was in contrast with that of antisense c-erbB_(2) ODN, which suppressed the progesterone production and reduced the percentage of luteal cells stained for c-erbB_(2) protein. On the other hand, both verapamil and CYX enhanced the inhibition of antisense c-erbB_(2) ODN. The result of the present investigation suggests that cAMP, Ca~(2+)-dependent pathway participates in the expression of protooncogene.

Key words: Luteal cells;c-erbB_(2);Antisense oligodeoxynucletoide;Progesterone

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Citing This Article：

Jin Xuan, Wang Lian, Zheng Yuehui, Zhong Zhisheng, Kuang Haibin. Effects of c-erbB_(2) on the hCG-induced progesterone production of rat luteal cells. Acta Physiol Sin 2000; 52 (1): (in Chinese with English abstract).