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The effects of cytokines produced by bone marrow endothelial cells on the regulation of hematopoiesis

Li Weimin, Huang Yanhong, Jiang Dezhao, Wang Qiru

Research Laboratory of Blood Physiology,Hunan Medical University.Changsha 410078,Hunan

Abstract

In this study, the effects of bone marrow endothelial cell conditioned medium (BMEC-CM) on hematopoietic progenitors and the expression of cytokines mRNA of BMEC were investigated. BMEC-CM was ultrafiltrated in Centriprep-10, an ultrafiltering concentrator. The retentate (MW>10 kD) and filtrate (MW<10 kD) were obtained. The effects of different components of BMEC-CM on the murine hematopoietic progenitors were examined.

Key words: Bone marrow endothelial cells;Serum free condition;Medium cytokine;Regulation of hematopoiesis

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Citing This Article：

Li Weimin, Huang Yanhong, Jiang Dezhao, Wang Qiru. The effects of cytokines produced by bone marrow endothelial cells on the regulation of hematopoiesis. Acta Physiol Sin 2000; 52 (1): (in Chinese with English abstract).