Issue Archive

Effect of intracerebralventricular injection of nitric oxide donor and nitric oxide synthase inhibitor on the spontaneous discharge of magnocellular neurons of paraventricular nucleus in the rat

Ji Yaping, Mei Jun

Department of Physiology,Xi^an Medical University.Xi^an 710061,Shaanxi

Abstract

The results showed that icv injection of NO donor sodium nitroprusside (SNP) had dose-dependent inhibitory effects on vasopressin (VP) secreting units in PVN. Icv injection of NOS inhibitor N~(#omega#)-nitro-L-arginine methyl ester (L-NAME) also inhibited all of the VP-secreting neurons examined. Both the drugs had no effect on almost all oxytocin (OT) secreting units. These results suggest that NO may differentially modulate the activities of OT and VP neurons.

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Ji Yaping, Mei Jun. Effect of intracerebralventricular injection of nitric oxide donor and nitric oxide synthase inhibitor on the spontaneous discharge of magnocellular neurons of paraventricular nucleus in the rat. Acta Physiol Sin 2000; 52 (1): (in Chinese with English abstract).