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Protective effect of hepatocyte growth factor on hepatocyte poisoning by carbon tetrachloride and related gene expression in rats

Zou Yuan, Gong Dezheng, Mei Maohua, Zhang Wanqin

Department of Physiology,Dalian Medical University.Dalian 116027,Liaoning

Abstract

The results showed that rhHGF could protect hepatocytes against CCl_(4) through preventing intracellular ALT and potassium ion leakage, thus suggesting a synergistic effect of rhHGF and EGF on cytoprotection, and high expression of HGF and its receptor/c-met mRNA in the liver treated with PH and CCl_(4) poisoning. The present study suggests that the expression of HGF and its receptor gene plays an important role in liver regeneration and repair.

Key words: Recombinant human hepatocyte;Growth factor epidermal growth factor;c-met carbon;Tetrachloride primary;Hepatocyte culture

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Citing This Article：

Zou Yuan, Gong Dezheng, Mei Maohua, Zhang Wanqin. Protective effect of hepatocyte growth factor on hepatocyte poisoning by carbon tetrachloride and related gene expression in rats. Acta Physiol Sin 2000; 52 (1): (in Chinese with English abstract).