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Effect of recombinant human interleukin-1#beta# on K~(+) channels of mice bone marrow stromal cells

Chen Nana, Wu Shuguang

Institute of Pharmaceutical Sciences,First Military Medical University.Guangzhou 510515,Guangdong

Abstract

In the present study, both cell-attached and inside-out mode of patch clamp technique were applied to detect the effect of recombinant human interleukin-1#beta# (IL-1#beta#) on K~(+) channels of mice bone marrow stromal cells. A 16.7 pS voltage-dependent K~(+) channel resembling the delayed rectifier K~(+) channel in excitable cells was identified and characterized.

Key words: Interleukin-1;Bone marrow stromal cell;K~(+) channels;Patch clamp;Signal transduction

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Citing This Article：

Chen Nana, Wu Shuguang. Effect of recombinant human interleukin-1#beta# on K~(+) channels of mice bone marrow stromal cells. Acta Physiol Sin 1999; 51 (6): (in Chinese with English abstract).