Issue Archive

Effects of bone marrow endothelial cell conditioned medium and its ultrafiltration-prepared components on the growth of CFU-GM

Wang Baohe, Wang Qiru

Laboratory of Blood Physiology,Hunan Medical University.Changsha 410078,Hunan

Abstract

Assays of granulocyte-macrophage colony-forming cell (CFU-GM) were performed to examine the effects of mBMEC-CM and its ultrafiltration-prepared components. It was not observed that mBMEC-CM and MW 3-10kD component had any significant influence on the growth of CFU-GM. However, MW>10 kD and 0.5-1 kD components enhanced the proliferation of CFU-GM, whereas MW 1-3 kD and <0.5 kD ones inhibited it. All these four components exerted their effects on the growth of CFU-GM in dose-dependent way.

Key words: Bone marrow endothelial cell;Conditioned medium;Growth factor;Growth inhibitor;CFU-GM

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Wang Baohe, Wang Qiru. Effects of bone marrow endothelial cell conditioned medium and its ultrafiltration-prepared components on the growth of CFU-GM. Acta Physiol Sin 1999; 51 (6): (in Chinese with English abstract).