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Changes of inhibitory amino acid in the monkey frontal cortex during a figure recognition guided sequential movement task

Shen Limin, Chen Yuchu

Shanghai Institute of Brain Research,Chinese Academy of Sciences.Shanghai 200031

Abstract

The levels of #gamma#-aminobutyric acid (GABA) and glycine (Gly) in the micro-dialysate from the monkey frontal cortex were measured by using the techniques of intracerebral microdialysis and high performance liquid chromatography with fluorescent detection while the animal was performing the Figure Recognition Motor Sequence (FRS) task. The probes were sited in the prefrontal cortex (PFC, 46 area), premotor cortex (PM, F7 and F2 areas) and primary motor cortex (MI, F1 area). The results showed that the level of GABA in PFC increased during the FRS task, whereas the level of Gly showed no significant changes.

Key words: Microdialysis;#gamma#-aminobutyric acid;Frontal cortex;Sequential movement;Rhesus monkey

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Citing This Article：

Shen Limin, Chen Yuchu. Changes of inhibitory amino acid in the monkey frontal cortex during a figure recognition guided sequential movement task. Acta Physiol Sin 1999; 51 (6): (in Chinese with English abstract).