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Effect of angiotensin II on c-fos expression and protein synthesis in cultured rat myocardial cells

Tan Shijin, Pan Jingyun, Zhan Chengyang, Zhu Xiaonan

Department of Cardiology,Shanghai Sixth People^s Hospital.Shanghai 200233；China

Abstract

The results showed that angiotensin II induced c-fos mRNA expression, increased protein content in a dose-dependent manner and stimulated ~(3)H-leucine incorporation rate. All these effects were blocked by angiotensin II receptor antagonist saralasin. The angiotensin II-induced expression of c-fos gene was also blocked by Ca~(2+) channel antagonist nicardipine.

Key words: Angiotensin Ⅱ;Saralasin nicardipine;c-fos mRNA;Protein synthesis

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Citing This Article：

Tan Shijin, Pan Jingyun, Zhan Chengyang, Zhu Xiaonan. Effect of angiotensin II on c-fos expression and protein synthesis in cultured rat myocardial cells. Acta Physiol Sin 1999; 51 (5): (in Chinese with English abstract).