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Antagonistic effects of melatonin on glutamate-induced neurotoxicity in rat hippocampal neurons

Gao Hongxiang, Zhang Liexiong

Department of Biology,East China Normal University.Shanghai 200062

Abstract

The effects of glutamate (Glu) and melatonin (MEL) on the evoked population spike (PS) following stimulation of the schaffer collateral fiber were studied by extracellular recording technique in perfused slices of rat hippocampus. Results suggest that the inhibitory action of MEL on Glu-induced neurotoxicity may be mediated by 5-HT receptors.

Key words: Glutamate;Neurotoxicity;Melatonin;Hippocampus slice of rat

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Citing This Article：

Gao Hongxiang, Zhang Liexiong. Antagonistic effects of melatonin on glutamate-induced neurotoxicity in rat hippocampal neurons. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).