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Effect of ET-1 antisense oligodeoxynucleotide on the hemodynamics of normal and experimental hypertensive rats

Du Yunpeng, Hu Qinghua, Wang Jianzhi, Wang Dixun

Department of Pathophysiology,Tongji Medical University.Wuhan 430030,Hubei

Abstract

It appears that (1) ET-1 might play an important role in central cardiovascular regulation in rats and (2) antisense ETASODN might be used in treatment of hypertension via inhibiting ET-1 production.

Key words: Hypertension;Endothelin-1;DNA antisense;Intracerebroventricular injection

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Citing This Article：

Du Yunpeng, Hu Qinghua, Wang Jianzhi, Wang Dixun. Effect of ET-1 antisense oligodeoxynucleotide on the hemodynamics of normal and experimental hypertensive rats. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).