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Hypoxia-induced increase in nerve activity of rabbit carotid body mediated by noradrenaline

Pang Lei, Miao Zhihui, Dong Li, Wang Yanling

Department of Physiology,Hebei Academy of Medical Sciences.Shijiazhuang 050021,Hebei

Abstract

The responses of 39 hypoxia-sensitive units of chemoreceptive afferent in sinus nerve to noradrenaline (NA) and its antagonist were recorded in carotid body-sinus nerve preparations from 30 rabbits. The present results suggest that (1) NA is not mainly concerned with spontaneous discharges of chemoreceptor sensitive to hypoxia, but does elicit an increase in spontaneous discharges, and (2) the increase of chemosensory unit discharges produced by hypoxia can be inhibited by yohimbine.

Key words: Carotid body;Unit discharge;Hypoxia;Noradenaline;Yohimbine

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Citing This Article：

Pang Lei, Miao Zhihui, Dong Li, Wang Yanling. Hypoxia-induced increase in nerve activity of rabbit carotid body mediated by noradrenaline. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).