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[AMPK: a novel target controlling inflammation.] [Article in Chinese]

YAO Feng, JI Guang-Yan, ZHANG Li^*

College of Clinical Medicine； Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China

Abstract

The AMP-activated protein kinase (AMPK) is a pivotal serine/threonine kinase participating in the regulation of glucose, lipid as well as protein metabolism and maintenance of energy homeostasis. Recent studies demonstrated that AMPK can also inhibit nuclear factor-κB, suppress the expression of inflammatory genes and attenuate inflammatory injury through phosphorylating its downstream targets including SIRT1, PGC-lα, p53 and FoxO3a. In addition, the widely used antidiabetic metformin also exerts its anti-inflammatory effects through activating AMPK. Therefore, AMPK is emerging as a promising novel target for the development of anti-inflammatory drugs. This review summarized the anti-inflammatory effects of AMPK and the underling molecular mechanisms.

Key words: AMP-activated protein kinase; inflammation; nuclear factor-κB; metformin

Received: 2011-11-05　　Accepted: 2012-01-17

Corresponding author: 张力　　E-mail: zhangli@cqmu.edu.cn

Citing This Article：

YAO Feng, JI Guang-Yan, ZHANG Li. [AMPK: a novel target controlling inflammation.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (3): 341-345 (in Chinese with English abstract).