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Increased release of orphanin FQ (OFQ) in brain of chronic morphine tolerant rats

Yuan Li, Han Zhou, Zhang Zhaokang, Han Jisheng

Neuroscience Research Institute,Beijing Medical University.Beijing 100083

Abstract

The changes in OFQ-immunoreactivity (OFQ-ir) content and release of cerebroventricular perfusate, periaqueductal gray (PAG) and amygadala of chronic morphine tolerant rats were measured with radioimmunoassay (RIA). The results suggested that in the later stage of chronic morphine treatment, large amount of OFQ was released from rat brain to antagonize the effect of opioids, which may play an important role in the development of morphine tolerance.

Key words: Orphanin FQ;Chronic morphine tolerance;Radioimmunoassay;Periaqueductal gray;Amygdala;Cerebroventricular perfusate

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Citing This Article：

Yuan Li, Han Zhou, Zhang Zhaokang, Han Jisheng. Increased release of orphanin FQ (OFQ) in brain of chronic morphine tolerant rats. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).