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Role of c-fos gene in the pulmonary surfactant synthesis of cultured alveolar type Ⅱ cells induced by endothelin-1

Luo Ziqiang, Sun Xiuhong, Qin Xiaoqun

Department of Physiology,Hunan Medical University.Changsha 410078,Hunan

Abstract

The effects of endothelin-1 (ET-1) on pulmonary surfactant (PS) synthesis of cultured alveolar type Ⅱ cells (ATⅡ) were observed. The role of c-fos gene in cellular signal transduction of ET-1 was studied by antisense technology. The results demonstrated that ET-1 can enhance PS synthesis of ATⅡ cells and ET-1 stimulating the expression of c-fos gene mediated by PKC is a major signal transduction pathway of modulating PS synthesis.

Key words: Endothelin-1;Alveolar type Ⅱcells;Pulmonary surfactant;Protein kinase C;c-fos gene

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Citing This Article：

Luo Ziqiang, Sun Xiuhong, Qin Xiaoqun. Role of c-fos gene in the pulmonary surfactant synthesis of cultured alveolar type Ⅱ cells induced by endothelin-1. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).