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Nestin expression during P19 neuron differentiation

Bian Wei, Yang Jing, Tang Ke, Jing Naihe

Shanghai Institute of Biochemistry,Chinese Academy of Science.Shanghai 200031

Abstract

Mouse nestin, an intermediate filament gene, is transiently expressed during the development of the central nervous system. In order to find the clue of its function during neural development, we tried to find out the gene expression pattern during the neuronal differentiation of P19 EC cells induced RA. RT-PCR showed that nestin was transiently expressed during P19 neuron differentiation, with a peak at day 4 of this process. However, BMP4, a neural precursor cell marker, was transiently expressed with its highest level at day 6, while NF160 kD a terminal differentiated neuronal marker, was increasingly expressed during the whole process.

Key words: Nestin;P19 neuron;BMP4;Neural filament

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Citing This Article：

Bian Wei, Yang Jing, Tang Ke, Jing Naihe. Nestin expression during P19 neuron differentiation. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).