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Effect of enkephalin on glial neurotrophic function related to the reduction of nitric oxide production

Wei Guangwei, Du Lina, Zhu Cuiqing, Tang Chongren, Cao Xiaoding, Wu Gencheng

Department of Neurobiology,Shanghai Medical University.Shanghai 200032

Abstract

ME-treated glia enhanced neuronal survival by 28% (P<0.05), and increased total neurite length per neuron by 11% (P<0.05), while the expression of GAP-43 mRNA by 26% (P<0.05). The effect of ME on NO production of glia was also studied in rat cortical glial culture. The result showed that different concentrations of ME (10~(-12), 10~(-10), 10~(-8), 10~(-6)mol/L) inhibited glial NO production.

Key words: Methionine enkephalin;Glial neuronal coculture;GAP-43;NO

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Citing This Article：

Wei Guangwei, Du Lina, Zhu Cuiqing, Tang Chongren, Cao Xiaoding, Wu Gencheng. Effect of enkephalin on glial neurotrophic function related to the reduction of nitric oxide production. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).