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Hemodynamic effects of agmatine and its cellular mechanism in anesthetized rats

Li Xiaotao, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results indicate that the hypotensive effect induced by iv agmatine may be attributed to the decrease in cardiac output resulting from depression of myocardial contractlity, as well as to the reduction in total peripheral resistance resulting from vasodilatation. These effects of agmatine may be mediated by imidazoline receptor and/or #alpha#_(2)-AR.

Key words: Agmatine;Hemodynamics;Imidazoline receptor;#alpha#_(2)-adrenoceptor

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Citing This Article：

Li Xiaotao, He Ruirong. Hemodynamic effects of agmatine and its cellular mechanism in anesthetized rats. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).