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Macrophage colony-stimulating factor production and c-fms expression in cultured rat aortic vascular smooth muscle cells

Zhu Dingliang, Gogusev J, Marche P

Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Second Medical University.Shanghai 200025；France

Abstract

The presence of mRNAs for MCSF and c-fms (which encoded MCSF receptor) was determined by Northern blot analysis. Their expressions were detectable in quiescent VSMCs and markedly increased after addition of serum. These data demonstrated for the first time the production of MCSF and the presence of MCSF receptor in cultured rat VSMCs. It is suggested that MCSF might modulate VSMCs functions via both autocrine and paracrine mechanisms. Rat VSMCs appear to be a suitable cell model for studying the cell proliferation effect of MCSF.

Key words: Vascular smooth muscle cell;Macrophage colonystimulating factor;Macrophage colonystimulating factor receptor

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Citing This Article：

Zhu Dingliang, Gogusev J, Marche P. Macrophage colony-stimulating factor production and c-fms expression in cultured rat aortic vascular smooth muscle cells. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).