Issue Archive

Potentiation of caffeine-induced contracture by raising extracellular potassium in frog skeletal muscle

Chen Keying, Zhu Peihong

Unit of Cell Signal Transduction,Shanghai Institute of Physiology,Chinese Academy of Sciences.Shanghai 200031

Abstract

The effect of raising extracellular potassium ([K~(+)]_(0)) on caffeine contracture was investigated, using small bundles dissected from frog anterior tibialis muscle. It is suggested that, at least in frog skeletal muscle, the high [K~(+)]_(0) induced potentiation of caffeine contracture is mainly due to an increase of myoplasmic free calcium.

Key words: Skeletal muscle;Ryanodine receptor;Caffeine;High potassium;Contracture

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Chen Keying, Zhu Peihong. Potentiation of caffeine-induced contracture by raising extracellular potassium in frog skeletal muscle. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).