Issue Archive

ET-1 induces the expression of prooncogene c-fos in cultured neonatal rat myocardial cells

Wu Bin, Wang Tinghuai, Zhu Xiaonan, Pan Jingyun

Department of Physiology,Sun Yat-sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

In the present study, the effect of endothelin-1 (ET-1) on the expression of protooncogene c-fos in cultured neonatal rat myocardial cells was investigated. The results suggest that in cultured neonatal cardiomyocytes, ET-1 induced c-fos gene expression is mediated by ET_(A) receptor with the participation of protein kinase C, while the voltage-dependent L-type Ca~(2+) channel is not involved.

Key words: Endothelin-1;c-fos;Cardiomyocyte

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Wu Bin, Wang Tinghuai, Zhu Xiaonan, Pan Jingyun. ET-1 induces the expression of prooncogene c-fos in cultured neonatal rat myocardial cells. Acta Physiol Sin 1999; 51 (1): 19-24 (in Chinese with English abstract).